Sexual dysfunction is a common side effect of antidepressants and can The three SSRIs, to an equal degree, significantly decreased libido. Until two years ago, Tali* and her husband used to have sex three or four times a week. She then began taking antidepressant medication. Find out what you can do to manage antidepressant sexual side effects. Simply put, antidepressants can turn the dial down on our sex drive.