Prozac and Zoloft are two types of antidepressant. along with the available dosages in milligrams (mg) and milligrams per milliliter (mg/ml). May increase by 25 mg at 1-week intervals; not to exceed mg qDay (Child- Pugh ): Not recommended; sertraline is extensively metabolized, and the. The dose regimen for sertraline in the treatment of depression has been well established. The starting dose, 50 mg/day, is the usually effective therapeutic dose.